NeoPeptide

NeoPeptide catalogs T-cell-defined neoantigens arising from somatic mutations and records peptide sequences, mutation sites, and major histocompatibility complex (MHC) restrictions to support neoantigen identification and cancer vaccine research.

Key Features:

• Comprehensive Data Collection: Aggregates neoantigen attributes including mutation sites, peptide sequences, and MHC restrictions curated from published literature and immunological databases.
• Resource Integration: Provides links to external resources for further characterization of neoantigen features.
• Regular Updates: Maintains updated entries reflecting newly identified and published neoantigens.

Scientific Applications:

• Neoantigen Target Identification: Supports identification of T-cell-defined neoantigen targets across cancer types by consolidating mutation and MHC information.
• Vaccine Candidate Selection: Facilitates selection and prioritization of neoantigen peptides for cancer vaccine development.
• Personalized Immunotherapy Research: Links patient-specific somatic mutations to neoantigen features to support personalized medicine and immunotherapeutic strategy development.

Methodology:

Systematic collection and curation of neoantigen data from published literature and immunological databases.