OGRDB

OGRDB curates inferred germline receptor gene sequences from AIRR-seq datasets to expand and improve germline gene reference sets for analysis of adaptive immune receptor repertoires.

Key Features:

• Comprehensive Germline Gene Reference Sets: Provides an extensive repository capturing diversity and polymorphism in human and animal germline receptor genes to supplement existing reference sets.
• Community-Driven Expert Review: Implements a community approach for expert review and publication of inferred germline sequences with supporting evidence.
• Support for V- and J- Sequence Inferences: Accepts sequence inferences from human B-cell receptor (BCR) light and heavy chains with a focus on variable (V) and joining (J) segments.
• Integration with AIRR-seq Data Analysis: Leverages tools and methods that infer gene sequences from AIRR-seq datasets to improve interpretation of complex genomic regions affected by multiple repeats, insertions, and deletions.

Scientific Applications:

• Immune response research: Enables analysis of adaptive immune receptor repertoires from AIRR-seq to study immune responses to diseases and the development of immune disorders.
• Immunogenetics: Provides more complete and representative germline gene sets for studying germline variability across populations.
• Vaccine development: Improves inference of receptor repertoires relevant to vaccine antigenicity and immune correlates.
• Personalized medicine: Supports individualized repertoire analysis and interpretation by supplying expanded germline references.

Methodology:

Inference of germline V and J gene sequences from AIRR-seq datasets using advanced bioinformatics tools that address challenges from repeats, insertions, and deletions.