OSuvm

OSuvm performs consensus survival analysis to assess the prognostic value of genes in uveal melanoma (UM), including implications for liver metastasis risk.

Key Features:

• Prognostic assessment: Estimates prognostic values of specific genes in UM using survival statistics.
• Survival metrics: Produces Kaplan-Meier survival plots and reports hazard ratios and log-rank test results.
• Cohort integration: Integrates gene expression profiles and clinical follow-up from four independent cohorts comprising 229 patients to assess consistency across datasets.
• Consensus analysis: Aggregates evidence across cohorts to identify genes with consistent prognostic associations.
• Biomarker evaluation: Has been used to evaluate the prognostic roles of previously reported UM biomarkers.

Scientific Applications:

• Prognostic biomarker discovery: Identification and validation of candidate molecular biomarkers associated with survival in uveal melanoma.
• Risk stratification: Assessment of gene-level associations with patient survival and potential risk of liver metastases.
• Cross-cohort validation: Comparative evaluation of prognostic signals across independent UM cohorts using gene expression and clinical follow-up data.

Methodology:

Performs Kaplan-Meier survival analysis with hazard ratio estimation and log-rank tests on integrated gene expression and clinical follow-up data from four independent cohorts totaling 229 patients.