OsteoporosAtlas

OsteoporosAtlas catalogs genes and microRNAs associated with osteoporosis to support genetic and functional analysis of the disease.

Key Features:

• Centralized Database: Consolidates literature-derived information on osteoporosis-related genes and miRNAs into a single curated resource.
• Data Extraction and Curation: Data were obtained by text-mining PubMed abstracts followed by manual curation and stored in a local MySQL database hosted on a Windows server.
• Extensive Gene and miRNA Repository: Includes 617 human encoding genes, 131 non-coding miRNAs, and 128 annotated functional roles linked to osteoporosis.
• Integrated Functional Analyses: Provides gene ontology and pathway analyses for annotated genes and miRNAs.

Scientific Applications:

• Facilitating Genetic Research: Supports identification and exploration of genes, loci, and miRNA associations implicated in osteoporosis pathogenesis.
• Supporting Drug Development: Enables analysis of genetic interactions and pathways relevant to therapeutic target identification.
• Enhancing Diagnostic and Preventive Strategies: Informs development of genetic biomarkers and risk assessment approaches for osteoporosis.

Methodology:

Text-mining of PubMed abstracts combined with manual curation, data storage in a local MySQL database on a Windows server, and inclusion of gene ontology and pathway analyses.