PCOSBase

PCOSBase provides a curated repository of proteins and associated annotations to support molecular research into polycystic ovarian syndrome (PCOS).

Key Features:

• Comprehensive protein collection: Contains 8,185 PCOS-related proteins and additionally includes proteins that interact with them to expand molecular context.
• Functional annotations: Maps proteins to 13,237 gene ontology terms, 1,004 pathways, and 7,936 domains.
• Tissue and disease mappings: Includes tissue localizations for 91 tissues, 29 disease classes, and associations with 1,928 diseases.
• Interaction network: Integrates 320,472 protein–protein interactions among PCOS-related and interacting proteins.
• Data sources: Aggregates proteins from various online databases and published expression studies.
• Curation and selection: Applies rigorous selection criteria and manual curation to ensure relevance to PCOS.
• Literature indexing: Indexes publications related to PCOS linked to the protein entries.

Scientific Applications:

• Pathogenesis research: Enables exploration of molecular mechanisms underlying PCOS through annotated proteins and interaction networks.
• Biomarker discovery: Supports identification of candidate biomarkers for PCOS via aggregated protein, pathway, and disease association data.
• Pathway and domain analysis: Facilitates pathway-level and domain-level analyses relevant to PCOS biology.

Methodology:

Proteins were collected from online databases and published expression studies, filtered using defined selection criteria, manually curated for gene ontologies, pathways, domains, tissue localizations and disease associations, interactions were integrated, and related publications were indexed.