PMBD

PMBD compiles curated associations between 949 microorganisms, 79 genes, and over 8,000 enzyme sequences sourced from the TrEMBL section of UniProt that are implicated in microbial biodegradation of plastics to support research on degradation mechanisms and enzyme function.

Key Features:

• Extensive Data Collection: Documents relationships between 949 microorganisms and plastics and identifies 79 genes implicated in plastic biodegradation based on literature curation.
• Enzyme Sequence Repository: Contains over 8,000 enzyme sequences predicted to participate in plastic biodegradation, sourced from UniProt TrEMBL.
• Automated Annotation: Enzyme sequences are automatically annotated using entries from the TrEMBL section of UniProt.
• Sequence Alignment Tool: Provides a sequence alignment tool for comparative analysis of enzymes involved in plastic degradation.
• Function Prediction Tool: Provides a function prediction tool to infer potential biodegradation activities of sequences.

Scientific Applications:

• Understanding Mechanisms: Facilitates exploration of genetic and enzymatic mechanisms underlying microbial plastic biodegradation.
• Biotechnological Innovations: Supports identification of candidate enzymes and genes for engineering or biotechnological development to enhance plastic degradation.
• Environmental Impact Studies: Enables assessment of microbial contributors and genetic factors relevant to environmental plastic biodegradation studies.

Methodology:

Data were compiled via literature searches; enzyme sequences were automatically annotated and sourced from the TrEMBL section of UniProt; the resource includes sequence alignment and function prediction tools.