QRISK3

QRISK3 calculates the 10-year risk of developing cardiovascular disease (CVD) for individual patients using the ClinRisk QRISK3 algorithm implemented in R.

Key Features:

• Algorithm Implementation: Implements ClinRisk's QRISK3 risk prediction algorithm in R to compute individual 10-year CVD risk.
• Validation and Transparency: Validated against the open-source QRISK3 reference implementation and the original QRISK3 SAS program to ensure concordance and reproducibility.
• Batch Cohort Scoring: Computes QRISK3 scores for individual records and large cohorts to support population-level analyses.

Scientific Applications:

• Risk Prediction Research: Provides a validated implementation of QRISK3 for investigations of cardiovascular risk factors and prediction performance.
• Epidemiological Analysis: Enables assignment of QRISK3 scores across cohorts for population health studies and outcome association analyses.
• Model Evaluation and Development: Facilitates evaluation, comparison, and refinement of CVD risk prediction models using a reproducible QRISK3 implementation.

Methodology:

The package implements the published QRISK3 risk prediction algorithm in R and was validated by comparison to the open-source QRISK3 implementation and the original QRISK3 SAS program.