RHPCG

RHPCG provides integrated multi-omics analysis and regulatory-motif annotation of the Hippo signaling pathway to investigate its role in cancer.

Key Features:

• Multi-Omics Analysis: Analyzes 21 core Hippo genes using genomic, epigenomic, and transcriptomic data from over 10,000 patients across 33 TCGA cancer types.
• Regulatory Motif Database: Catalogs 11 regulatory motif types linking 180 microRNAs (miRNAs), 6,182 long non-coding RNAs (lncRNAs), 728 circular RNAs (circRNAs), and 335 protein-coding genes to core Hippo pathway genes.
• Visualization Tools: Provides visualization of regulatory relationships within the Hippo signaling network to support interpretation of multi-omics and motif data.

Scientific Applications:

• Molecular mechanism analysis: Enables investigation of Hippo pathway molecular mechanisms in cancer using integrated genomic, epigenomic, and transcriptomic evidence.
• Biomarker and therapeutic target discovery: Facilitates identification of candidate biomarkers and therapeutic targets within the Hippo signaling network by combining motif annotations with expression and alteration data.
• Cancer-specific dysregulation analysis: Supports analysis of pathway dysregulation across diverse cancers, including breast cancer and lung cancer, using TCGA cohort comparisons.

Methodology:

Integrated multi-omics data (genomic, epigenomic, transcriptomic) from TCGA across >10,000 patients and 33 cancer types and systematically cataloged regulatory motifs (miRNAs, lncRNAs, circRNAs, protein-coding genes) associated with 21 core Hippo genes.