RRMdb

RRMdb provides rapid identification and evolutionary-oriented annotation of RNA-recognition motif (RRM) domains within protein sequences to support studies of RNA metabolism.

Key Features:

• Extensive Sequence Collection: Contains approximately 57,000 representative RRM domain sequences organized into 415 distinct families.
• Rapid Identification and Annotation: Enables rapid identification and detailed annotation of RRM domains within protein sequences.
• Family Classification and Annotation Links: Associates each family, where possible, with available literature and structural data.
• Evolutionary Relationships Network: Arranges families into a network based on sequence similarities to assess evolutionary relationships among RRM families.

Scientific Applications:

• Annotation of RNA-binding Domains: Supports identification and annotation of RRM domains involved in splicing, editing, export, degradation, and regulation of translation.
• RNA–Protein Interaction Studies: Enables studies of RNA–protein interactions and broader RNA biology by providing annotated RRM sequences and family classifications.
• Evolutionary Analyses: Provides evolutionary insights to inform studies on the functional evolution of RNA-binding proteins.

Methodology:

Construction involved collecting RRM domain sequences from a wide array of sources, grouping sequences into families based on sequence similarities, linking families to available literature and structural data, and arranging families into a network reflecting sequence-similarity relationships.