SieveSifter

SieveSifter visualizes and analyzes sieve analyses from HIV-1 vaccine efficacy trials to identify viral genetic signatures and vaccine-induced selective pressures associated with partial protection.

Key Features:

• Visualization: Visualizes sieve analyses and genetic sequence comparisons derived from HIV-1 vaccine efficacy trials.
• Aggregated sequence data: Aggregates and organizes viral genetic sequence data from the HVTN 502/Step, RV144/Thai, HVTN 503/Phambili, and HVTN 505 trials for comparative analysis.
• Rapid reinterpretation: Enables reanalysis of sieve effects across trial datasets to support hypothesis testing and comparative studies.
• Methodology development support: Provides comprehensive trial-derived datasets to support development and benchmarking of novel sieve analysis methodologies.

Scientific Applications:

• Elucidation of immune specificities: Compare sequences from vaccine and placebo recipients against the vaccine sequence to identify functional specificities of vaccine-induced immune responses.
• Detection of correlates: Identify viral sequence characteristics associated with partial protection and vaccine-associated selection.
• Vaccine design guidance: Inform HIV-1 vaccine antigen selection and immunogen design by revealing molecular interactions between vaccine-elicited responses and viral variants.

Methodology:

Performs sieve analysis on genetic sequence data from the HVTN 502/Step, RV144/Thai, HVTN 503/Phambili, and HVTN 505 trials to identify sequence differences associated with vaccine-induced immune pressure.