Spaniel

Spaniel provides an R package for analysis and sharing of spatial transcriptomics data generated by spatially resolved sequencing of complete transcriptomes from barcoded regions within intact tissue samples.

Key Features:

• Framework for Analysis: Provides a structured framework to process and analyze spatial transcriptomics datasets from barcoded tissue regions.
• Data Sharing Capabilities: Supports sharing of spatial transcriptomics datasets to facilitate collaboration and reproducibility.

Scientific Applications:

• Cellular-resolution analysis: Enables examination of cellular function and complete transcriptomes at high spatial resolution within intact tissues.
• Gene expression pattern analysis: Supports analysis of spatial gene expression patterns across tissue regions.
• Cell–cell interactions: Assists investigation of cell–cell interactions using spatially resolved transcriptomic profiles.
• Spatial organization studies: Facilitates study of tissue spatial organization by relating transcriptomic variation to anatomical location.
• Disease mechanism research: Contributes spatial context for gene expression changes relevant to disease mechanisms.

Methodology:

Implemented in R, Spaniel processes and interprets large-scale spatially resolved transcriptomic datasets derived from sequencing of barcoded regions within intact tissue samples.