SweGen

SweGen provides allele frequency data for genetic variants from Swedish population genomic studies to support population-specific variant interpretation as part of the SweFreq resource.

Key Features:

• Population-specific allele frequencies: Provides detailed allele frequency data derived from large-scale genomic studies conducted within Sweden.
• Variant identifier queries: Supports queries by variant identifiers such as rsIDs.
• Comparative frequency analysis: Enables comparison of Swedish variant frequencies to external global datasets for epidemiological and population-genetic analyses.

Scientific Applications:

• Population prevalence assessment: Facilitates assessment of variant prevalence within the Swedish population for downstream analyses.
• Disease association studies: Supports studies of genetic predisposition to diseases such as cancer and cardiovascular conditions by providing population frequency baselines.
• Cohort enrichment analyses: Has been used to evaluate whether the Factor V Leiden (FVL) polymorphism is overrepresented in glioblastoma patient cohorts with venous thromboembolic events.

Methodology:

Aggregates allele frequency data from large-scale Swedish genomic studies and provides comparative analyses against external global datasets.