SyntDB

SyntDB catalogs long noncoding RNAs (lncRNAs) and their orthologous relationships across twelve primate species, including human, to support evolutionary and functional genomics analyses.

Key Features:

• Species coverage: Data covers twelve primate species, including human.
• Extensive collection: Houses thousands of uniquely identified lncRNAs predicted via a computational pipeline using publicly available RNA-Seq data from diverse tissues and organs.
• Orthology relationships: Provides detailed annotations of orthologous relationships between human lncRNAs and lncRNAs in other primate species at large scale.
• Conservation-based prioritization: Emphasizes conserved lncRNA sequences to aid identification of candidates with potential biological significance for functional studies.

Scientific Applications:

• Evolutionary studies: Facilitates analysis of evolutionary conservation and divergence of lncRNAs across primates.
• Functional genomics: Supports selection of conserved lncRNAs for experimental functional assays related to gene regulation, development, and disease.
• Comparative genomics: Enables comparative analyses of lncRNA sequence and orthology across primate genomes.

Methodology:

Integration of publicly available RNA-Seq data from diverse tissues and organs and prediction of lncRNAs using a specialized computational pipeline, followed by annotation of orthologous relationships across the twelve primate species.