Synteny Browser

Synteny Browser visualizes regions of conserved synteny between genomes to support comparative genomics analyses and identification of conserved, functionally relevant genes.

Key Features:

• Synteny visualization: Visualizes conserved syntenic regions and block-level alignments between two genomes.
• Selective display of genome features: Filters and highlights genomic features within syntenic blocks based on annotated biological attributes such as type, function, and phenotype association.
• True orientation display: Represents the orientation of the comparison genome relative to the reference within syntenic blocks.
• Gene symbol visibility: Displays gene symbols for genomic features to support identification and cross-referencing.
• Anchors visualization: Displays anchors that delineate syntenic blocks.

Scientific Applications:

• Comparative genomics (Mus musculus – Homo sapiens): Enables detailed comparisons of conserved genomic regions between laboratory mouse (Mus musculus) and human (Homo sapiens).
• Evolutionary biology: Supports analysis of conservation and rearrangement of genomic regions across species.
• Functional genomics: Facilitates identification of functionally relevant genes within conserved syntenic contexts.
• Genetic disease studies: Assists in mapping and comparing candidate loci conserved between species for disease research.

Methodology:

Implemented on a genome-agnostic software platform and operable for any two genomes when syntenic block coordinates are provided and biological feature attributes are available in standard bioinformatics file formats.