TYGS

TYGS infers genome-scale phylogenies and estimates species and subspecies boundaries using type (strain) genomes to support genome-based microbial taxonomy.

Key Features:

• Genome-Scale Phylogenies: Infers phylogenetic relationships at the genome scale.
• Species and Subspecies Boundary Estimation: Estimates species and subspecies boundaries using both user-defined and automatically determined closest type genome sequences.
• Analysis of Type (strain) Genomes: Analyzes type (strain) genomes for taxonomic placement and comparison.
• Comprehensive Nomenclature Access: Provides nomenclatural data including synonymy and associated taxonomic literature.
• Integration with Databases and High-Throughput Automation: Integrates genomic, taxonomic, and nomenclatural information with a large, continuously updated database and performs automated high-throughput analyses.

Scientific Applications:

• Classification of Novel Taxa: Supporting the classification of new genera, species, and subspecies based on genome data.
• Delineation of Taxonomic Boundaries: Providing precise boundary estimates for identification and delimitation of microbial taxa.
• Resolution of Complex Taxonomic Cases: Informing taxonomic decisions such as distinguishing between previously proposed subspecies of Salmonella enterica at a species level.

Methodology:

Analyzes type (strain) genomes to infer genome-scale phylogenies and to estimate species and subspecies boundaries using user-defined and automatically determined closest type genome sequences; integrates genomic data with taxonomic and nomenclatural information and automates high-throughput analyses.