Target Gene Notebook

Target Gene Notebook aggregates and curates genetic, genomic, and functional datasets to support therapeutic target evaluation and evidence integration.

Key Features:

• Integration and Curation: Integrates public genome annotations with proprietary datasets to build a comprehensive, up-to-date knowledge base for target evaluation.
• Technical Architecture: Implements a Java backend serving gene-specific SQLite databases with JavaScript components for content delivery.
• Data Access and Analysis: Provides automated access to genetic association, expression, and protein quantitative trait loci (QTL) datasets and exposes credible set information and colocalization analysis outputs.
• Collaborative Annotation: Supports group curation and multi-curator literature annotation to compile and refine target-related evidence.

Scientific Applications:

• Target prioritization: Links genetic associations to biological function and potential drug targets to inform therapeutic selection.
• Evidence integration: Combines genetic association, expression, and protein QTL data to consolidate orthogonal lines of evidence for targets.
• Knowledge-base construction: Facilitates generation of durable, curated target knowledge bases through collaborative annotation and dataset integration.

Methodology:

Java backend serving gene-specific SQLite databases; automated retrieval and integration of genetic association, expression, and protein QTL datasets; provision of credible set information and colocalization analysis outputs.