VDJbase

VDJbase provides a database of immunoglobulin (Ig) and T cell receptor (TR) gene genotypes and haplotypes inferred from adaptive immune receptor repertoire sequencing (AIRR-seq) datasets to support analysis of genetic variation in adaptive immune receptor loci.

Key Features:

• AIRR-seq Derived Genotype and Haplotype Data: Stores immunoglobulin (Ig) and T cell receptor (TR) gene genotypes and haplotypes inferred from adaptive immune receptor repertoire sequencing datasets.
• Comprehensive Gene Sequence Repository: Provides complete sets of gene sequences representing allelic variation within Ig and TR loci.
• Allele and Gene Representation Analysis: Enables identification of alleles and genes showing over-representation across datasets based on genotype, haplotype, or gene expression metrics.
• Population-Level Genetic Variation Data: Supports comparison of allele frequencies and gene expression patterns across different populations.

Scientific Applications:

• Immunogenetics Research: Investigates genetic diversity within immunoglobulin and T cell receptor gene loci.
• Adaptive Immune Repertoire Analysis: Analyzes AIRR-seq datasets to study genotype and haplotype variation in adaptive immune receptors.
• Disease Susceptibility Studies: Examines genetic variation in Ig and TR loci associated with immune-related diseases.

Methodology:

VDJbase aggregates immunoglobulin (Ig) and T cell receptor (TR) gene sequences, genotypes, and haplotypes inferred from adaptive immune receptor repertoire sequencing (AIRR-seq) datasets and organizes them for analysis of allele representation, haplotype structure, and population-level genetic variation.