VISDB

VISDB compiles and annotates viral integration sites in the human genome to support analysis of virus–host genomic interactions and their roles in disease.

Key Features:

• Curated Viral Integration Site Repository: Contains 77,632 experimentally reported viral integration sites for DNA viruses (HBV, HPV, EBV, AAV2, MCV) and RNA retroviruses (HIV, HTLV-1, MLV, XMRV).
• Comprehensive Genomic Annotation: Annotates integration sites with target genes, nearby genes, nearest transcription start sites, chromosome fragile sites, CpG islands, and viral and host genomic sequences.
• Oncogene and Tumor Suppressor Gene Annotation: Includes curated information on oncogenes and tumor suppressor genes associated with viral integration events.
• Virus–Host Interaction Data: Links integration sites with regulatory features including non-coding RNAs (ncRNAs), target gene expression, and microRNA expression across multiple cancer types.
• Integration Site Visualization: Provides visualization of individual integration events, clusters of viral integration sites, nearby DNA elements, and virus–host regulatory interactions.

Scientific Applications:

• Virus–Host Genome Interaction Analysis: Investigates genomic patterns and regulatory effects of viral integration in the human genome.
• Cancer Genomics Research: Studies viral integration events associated with oncogenes, tumor suppressor genes, and cancer development.
• Viral Pathogenesis Studies: Explores molecular mechanisms by which viruses alter host gene regulation through genomic integration.

Methodology:

VISDB aggregates viral integration sites from published literature and public datasets, annotates each site with genomic features including genes, transcription start sites, fragile sites, and CpG islands, and integrates virus–host regulatory information such as non-coding RNA and microRNA associations.