VMH

VMH integrates comprehensive data on human metabolism, gut microbial interactions, disease associations, nutritional data, and metabolic reconstructions to enable metabolic modeling and analysis.

Key Features:

• Comprehensive Metabolic Data: Contains 5,180 unique metabolites, 17,730 unique biochemical reactions, 3,695 human genes, 255 Mendelian diseases, 818 microbial species, 632,685 microbial genes, and 8,790 food items.
• Interlinked Resources: Organizes content into five interconnected resources: 'Human metabolism', 'Gut microbiome', 'Disease', 'Nutrition', and 'ReconMaps'.
• Metabolic Reconstructions and Modeling: Hosts metabolic reconstructions of human and gut microbes that are amenable to metabolic modeling.
• Data Visualization Tools: Provides seven comprehensive human metabolic maps for visualization of metabolic networks.
• Nutrition Designer: Includes a Nutrition Designer component for exploring the impact of dietary components on metabolism.
• Integration with External Resources: Links entities to 57 external web resources.

Scientific Applications:

• 'Omics' data integration: Supports integration and analysis of 'omics' data to investigate metabolic pathways.
• Complex disease research: Facilitates exploration of metabolic pathway associations with complex diseases, including Mendelian diseases.
• Microbiome–nutrition–metabolism interactions: Enables study of interactions among human metabolism, gut microbiome dynamics, and nutritional factors to investigate disease etiology and progression.

Methodology:

Meticulous curation and integration of data from diverse biological domains and a database architecture supporting metabolic modeling and visualization.