VizGVar

VizGVar visualizes genetic variation by integrating genomic and proteomic data to display SNPs and somatic mutations within exons, genes, and protein domains for analysis.

Key Features:

• Integration with Comprehensive Databases: Connects to Ensembl for protein motifs, domains, genes, and exons and incorporates annotated SNPs and somatic variations from PharmGKB and COSMIC.
• Advanced Visualization Techniques: Represents different types of genetic variations using colored curves that map mutation locations within genomic and protein coordinates.
• Hierarchical Data Representation: Aggregates and displays patterns across multiple biological levels to reflect relationships among exons, genes, and protein domains.

Scientific Applications:

• Disease Genomics: Visualizes SNPs and somatic mutations within genes and protein domains to assist identification of potential biomarkers for diagnosis and treatment.
• Mutation Pattern Analysis: Integrates Ensembl, PharmGKB, and COSMIC annotations to facilitate exploration of mutation patterns with potential clinical significance.

Methodology:

Implemented a new information architecture tailored to enhance visualization of genetic and protein data.