WHISCY

WHISCY predicts protein-protein interfaces by combining surface conservation and structural information to calculate prediction scores for surface residues.

Key Features:

• Conservation-based prediction: Uses sequence alignment to calculate a prediction score for each surface residue of the protein.
• Structural information integration: Incorporates structural information alongside conservation data to improve interface prediction accuracy.
• Combined predictor capability: Predictions can be combined with ProMate interface predictions to generate an even more accurate predictor.

Scientific Applications:

• Protein-protein interface identification: Identifies interacting residues as a first step toward understanding protein-protein interactions at a structural level.
• Data-driven protein-protein docking: Drives the HADDOCK docking program to generate near-native unbound docking solutions for protein complexes.

Methodology:

WHISCY calculates prediction scores for surface residues using sequence alignment-based conservation analysis combined with structural information.