Yvis

Yvis provides high-density visualization and analysis of large antibody sequence and structure datasets using the Collier de Diamants alignment method to identify conserved regions and critical residues.

Key Features:

• High-Density Data Visualization: Implements the Collier de Diamants technique to generate detailed visualizations of antibody sequence alignments for large datasets.
• Integrated Structural Database: Maintains an integrated structural database updated weekly that links sequence information with structural insights.
• Advanced Search and Filter Options: Provides search and filter functionalities to refine queries across antibody sequence and structural data.
• Hypothesis Formulation Support: Facilitates formulation of hypotheses about critical residues and sequence-structure relationships influencing antibody properties and interactions.

Scientific Applications:

• Immunology and Structural Biology Research: Enables investigation of sequence-structure relationships and conserved motifs in antibody repertoires.
• Diagnosis and Therapy Development: Supports analysis of antibody interactions and properties relevant to diagnostic tool and therapeutic antibody development.
• Experimental Biology Research: Provides insights into antibody behavior and function to inform experimental studies.

Methodology:

Uses the Collier de Diamants high-density alignment visualization to examine sequence alignments, identify conserved regions and critical residues, and link sequence data with structural information from an integrated structural database updated weekly.