Antigen-Antibody Complex Database (AACDB)

The Antigen-Antibody Complex Database (AACDB) provides a comprehensive collection of 7498 manually processed antigen-antibody complexes with rectified annotation errors, integrated antibody developability data, and antigen-drug target relationships to support immunoinformatics research and antibody therapy development.

Key Features:

• Manually processed complexes: Contains 7498 antigen-antibody complexes with manual processing to ensure accuracy and detail.
• Annotation error correction: Rectifies annotation errors found in the PDB database.
• Antibody developability data: Integrates data on antibody developability properties.
• Antigen-drug target relationships: Integrates data on antigen-drug target relationships.
• Paratope and epitope annotation: Includes comprehensive paratope and epitope annotation information.

Scientific Applications:

• Immunoinformatics research: Serves as a benchmark dataset for immunoinformatics research through comprehensive epitope and paratope annotations.
• Antibody therapy development: Assists development of new antibody therapies by providing integrated developability and target relationship data.
• Antigen-antibody interaction analysis: Supports elucidation of complex interactions between antibodies and antigens for drug development.

Methodology:

Manual processing of antigen-antibody complex data with annotation error correction from the PDB database; integration of antibody developability data and antigen-drug target relationships.