AAgAtlas

AAgAtlas compiles a curated catalog of human autoantigens to support research into autoantibody responses and the molecular mechanisms of autoimmune diseases.

Key Features:

• Extensive Database: AAgAtlas 1.0 compiles data from over a thousand peer-reviewed publications cataloging 1126 autoantigens associated with 1071 distinct human diseases.
• Functional Annotations and Literature Evidence: Records include gene functional annotations and supporting evidence extracted from the scientific literature.
• Text-Mining and Manual Curation: Data collection employed automated text-mining techniques combined with meticulous manual curation to validate autoantigen–disease associations.

Scientific Applications:

• Disease Mechanism Exploration: Enables investigation of specific autoantigens' roles in pathogenesis and disease progression.
• Biomarker Discovery: Supports identification of candidate autoantigens for diagnostic or disease-monitoring biomarkers.
• Therapeutic Target Identification: Facilitates nomination of autoantigens as targets for therapies aimed at modulating immune responses.
• Cross-Disease Analysis: Allows comparative analyses to identify shared autoantigens and common pathways across multiple diseases.

Methodology:

Automated text-mining of peer-reviewed publications combined with manual curation to extract and validate autoantigen–disease associations.