ABC-HuMi

ABC-HuMi catalogs biosynthetic gene clusters (BGCs) from human-associated microbial genomes to map the biosynthetic potential across the gut, oral cavity, skin, respiratory tract, and urogenital system.

Key Features:

• Extensive Cataloging: Contains 19,218 representative BGCs sampled from multiple human body sites.
• Integration and Data Sources: Integrates genomic data from major human microbiome sequence repositories and comprehensive microbiome sequencing projects.
• Advanced Prediction and Annotation Tools: Applies state-of-the-art BGC prediction algorithms and bioinformatics tools for annotation and prediction of novel gene clusters.
• Body-site-resolved Coverage: Provides BGC annotations linked to specific body sites (gut, oral cavity, skin, respiratory tract, urogenital system) to enable comparative analyses.

Scientific Applications:

• Natural Product Discovery: Enables identification of candidate bioactive compounds encoded by human-associated microbes for therapeutic investigation.
• Comparative Biosynthetic Profiling: Supports comparison of biosynthetic repertoires across gut, oral, skin, respiratory, and urogenital microbiomes to study microbial ecology.
• Synthetic Biology and Drug Discovery: Provides annotated BGCs as a resource for research in synthetic biology and drug discovery.

Methodology:

Aggregates genomic data from comprehensive microbiome sequencing projects and major human microbiome sequence repositories, applies BGC prediction algorithms and bioinformatics tools to predict and annotate BGCs, and validates predictions through computational analyses.