ABC portal

ABC portal provides a curated repository and analysis platform for single-cell transcriptomic data focused on the development, differentiation, and disorders of blood and immune cells.

Key Features:

• Comprehensive Dataset Repository: Contains 198 curated single-cell transcriptomic datasets relevant to haematopoiesis and blood/immune cell biology.
• Unified Re-annotation Reference: Datasets were re-annotated using a manually curated unified single-cell reference tailored to haematopoietic stem and progenitor cells.
• Analysis Modules: Implements modules for cell-cell communication analysis and disease-related gene signature evaluation.
• Customized Sample Selection: Enables selection of samples based on metadata criteria for targeted and comparative analyses.
• Multi-Cell Type Analysis: Supports selection and joint analysis of multiple cell types to investigate cellular interactions.

Scientific Applications:

• Haematopoiesis research: Supports investigation of development and differentiation of haematopoietic stem and progenitor cells.
• Blood and immune disorder analysis: Facilitates analysis of transcriptional changes and molecular features in blood and immune diseases.
• Cell-cell communication studies: Aids elucidation of intercellular communication networks and signaling pathways among blood and immune cell types.
• Biomarker and therapeutic target discovery: Enables disease-related gene signature analyses to identify biomarkers and candidate therapeutic targets.

Methodology:

Integrated datasets were re-annotated using a manually curated unified single-cell reference specifically tailored for haematopoietic stem and progenitor cells.