Aliment to Bodily Condition knowledgebase (ABCkb)

Aliment to Bodily Condition knowledgebase (ABCkb) provides an integrated graph database linking plant-derived products to human genes, pathways, and specific health indications to elucidate molecular mechanisms underlying diet-related health outcomes.

Key Features:

• Stepwise mapping: Establishes explicit links from plants to plant-derived products, then to human genes, pathways, and specific health indications.
• Data integration: Consolidates data from 11 curated sources to support structured relationships between botanical entities and human biology.
• Literature-derived relationships: Incorporates relationships extracted from Medline abstracts.
• Graph database: Organizes entities and relationships within a graph database framework to support complex queries and analyses.
• Containerized deployment: Provides a Docker container for packaging the computational resource.

Scientific Applications:

• Hypothesis generation: Enables generation of nutritive hypotheses linking plant phytochemicals to molecular mechanisms in humans.
• Diet-related disease research: Supports investigation of chronic diet-related diseases, including obesity and type 2 diabetes.
• Dietary and agricultural guidance research: Informs research that can connect dietary components to recommendations and agricultural practices.
• Phytochemical–biology exploration: Facilitates exploration of connections between plant phytochemicals and their effects on human genes and pathways.

Methodology:

Consolidates data from 11 curated sources and relationships extracted from Medline abstracts, and organizes the aggregated information within a graph database; the resource is packaged in a Docker container.