ABPEPserver

ABPEPserver analyzes substitutant peptides produced by aberrant protein translation to document their expression, gene-association signatures, and potential as cancer immunotherapy targets across CPTAC tumor proteomes.

Key Features:

• Large-Scale Tumor Proteomics Analysis: Integrates proteomic data from eight tumor types sourced from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) to profile substitutant expression across cancers.
• Gene-Association Signatures: Computes and reports gene-association signatures linked to substitutant peptides to reveal biological associations with gene expression.
• Comparative Enrichment Analysis: Compares substitutant enrichment between tumor tissues and adjacent normal tissues to identify cancer-specific expression patterns.
• Immunotherapy Candidate Identification: Provides a curated list of substitutant peptides prioritized as potential candidates for immunotherapy development.

Scientific Applications:

• Aberrant Protein Production Profiling: Enables systematic exploration and cataloging of novel antigens arising from aberrant translation in human cancers.
• Cancer Antigen Discovery for Immunotherapy: Supports discovery and prioritization of substitutant peptides as candidate targets for cancer immunotherapy.
• Proteomic Comparative Analysis: Facilitates comparative analysis of large-scale proteomic datasets to investigate molecular underpinnings of tumor versus adjacent normal tissues.

Methodology:

Processes and presents high-throughput proteomic data from CPTAC, focusing on substitutants identified as products of aberrant translation and performing expression and enrichment comparisons and gene-association analyses.