Acinetobase

Acinetobase provides a curated repository of genetic and phenotypic data for Acinetobacter strains, particularly Acinetobacter baumannii, to enable selection and comparative analysis of isolates.

Key Features:

• Extensive Data Collection: Curates genetic and phenotypic data across a wide array of Acinetobacter strains, capturing genomic diversity and associated traits.
• Phenotypic and Genetic Insights: Includes annotations of macrocolony morphologies, virulence in vitro and in vivo, natural competence levels, capsular polysaccharide structures, and cellular densities.
• Gene Presence/Absence Documentation: Records presence or absence of specific genes and physiological processes to link genotypes with phenotypes.
• Strain Selection Support: Links genotype and phenotype data to facilitate selection of isolates tailored to specific biological inquiries.

Scientific Applications:

• Experimental Design: Enables selection of isolates with defined genotypic or phenotypic characteristics for laboratory and in vivo studies.
• Comparative Genomics: Supports analyses of genomic heterogeneity and limited core genome across Acinetobacter strains.
• Antimicrobial Resistance and Stress Response Studies: Facilitates analysis of antimicrobial resistance, desiccation resistance, disinfectant tolerance, human serum resistance, and oxidative stress responses.
• Virulence and Morphology Research: Enables investigation of virulence determinants, macrocolony morphologies, natural competence, and capsular polysaccharide structure effects.

Methodology:

Documents and curates genetic and phenotypic measurements, including annotations of gene presence/absence and recorded phenotypic trait data.