ADAS-viewer

ADAS-viewer visualizes and integrates genomic, transcriptomic, methylation, and miRNA data across seven brain regions to interrogate alternative splicing, transcript- and exon-level changes, and genetic and epigenetic regulatory effects in Alzheimer's disease.

Key Features:

• Multi-Omics Data Integration: Consolidates genomic, transcriptomic, methylation, and miRNA datasets from seven brain regions: cerebellum, temporal cortex, dorsolateral prefrontal cortex, frontal pole, inferior frontal gyrus, parahippocampal gyrus, and superior temporal gyrus.
• Cross-Cohort Analysis: Incorporates data from three independent cohort datasets to enable cross-study comparisons.
• Alternative Splicing Investigation: Identifies functional changes at transcript and exon levels with a focus on alternative splicing events.
• Regulatory Effects Analysis: Assesses genetic and epigenetic regulatory mechanisms associated with observed molecular changes.
• Visualization Capabilities: Produces visual representations of integrated multi-omics results across brain regions to facilitate pattern recognition and candidate biomarker identification.

Scientific Applications:

• Biomarker discovery: Identify potential biomarkers for early diagnosis or progression monitoring of Alzheimer's disease using integrated multi-omics signals.
• Regional molecular characterization: Investigate region-specific molecular alterations that may contribute to heterogeneity in AD pathology.
• Regulatory interplay analysis: Explore interactions among genetic, epigenetic, and transcriptomic factors in the context of neurodegeneration.

Methodology:

Computational methods explicitly include data normalization, data integration, and visualization algorithms applied to multi-omics datasets.