ADCdb

ADCdb provides a curated database of antibody-drug conjugates (ADCs), including detailed pharma-information and literature-reported biological activities to support ADC design and evaluation.

Key Features:

• Extensive Data Collection: Contains 6,572 ADC entries categorized by development stage: 359 ADCs approved by the FDA or in clinical trial pipelines, 501 in preclinical testing, 819 with in-vivo testing data, 1,868 with cell line/target testing data, and 3,025 lacking in-vivo/cell line/target testing data.
• Comprehensive Pharma-Information: Each entry includes explicit pharma-information describing the chemical and biological properties of ADCs, including antibody components and cytotoxic payloads.
• Literature-Reported Activities: Compiles 9,171 literature-reported activities derived from sources such as clinical trial pipelines, model organisms, and patient/cell-derived xenograft models.
• Multi-Perspective Integration: Integrates data across development stages and testing types to provide a holistic view of each ADC's potential efficacy and safety profile.

Scientific Applications:

• Drug Design and Development: Enables comparison and analysis of existing ADCs to inform the design of new ADC candidates.
• Clinical Research: Provides biological activity and development-stage data to support evaluation of ADCs in clinical trial pipelines.
• Preclinical Studies: Supplies preclinical and in-vivo/cell line testing data to aid optimization of ADC candidates prior to human studies.

Methodology:

Manual curation, compilation of literature-reported activities, and categorization of ADC entries by development stage.