ADeditome

ADeditome maps A-to-I RNA editing events in Alzheimer's disease to annotate their genomic locations and potential functional impacts.

Key Features:

• Extensive Database: catalogs 1,676,363 A-to-I RNA editing sites detected across 1,524 samples from nine brain regions using data from ROSMAP, MayoRNAseq, and MSBB.
• Functional Annotations: provides annotations linking edits to AD stages and to effects on gene expression, protein recoding, alternative splicing, and miRNA regulation, with emphasis on Alzheimer's-related genes.
• Pathological Insights: identifies 108,010 editing events predicted to promote AD progression, 26,168 events predicted to inhibit progression, and 5,582 brain-region-specific events with dual roles.
• Multi-layer Data Integration: integrates multiple layers of genomic data to support comprehensive functional annotation of RNA edits.
• Systematic Detection: applies advanced bioinformatics techniques for systematic detection and annotation of A-to-I editing events.

Scientific Applications:

• Pathology Exploration: enables investigation of molecular mechanisms underlying AD by linking specific RNA edits to gene function and brain-region specificity.
• Precision Medicine: supports identification of individualized therapeutic targets by associating particular RNA edits with disease progression and region-specific effects.
• Drug Research: facilitates discovery of therapeutic strategies aimed at modulating A-to-I RNA editing processes relevant to AD.

Methodology:

Employs advanced bioinformatics techniques to systematically detect and annotate A-to-I RNA editing events and integrates multiple layers of genomic data for comprehensive functional annotation.