ADmeth

ADmeth aggregates a curated compendium of differentially methylated genes, genomic regions, and CpG sites associated with Alzheimer's disease to support epigenetic studies and biomarker discovery.

Key Features:

• Comprehensive catalog: Contains 16,709 AD-related differential methylation items, comprising 209 genes, 2,229 genomic regions, and 14,271 CpG sites.
• Manual curation: Entries are extracted and verified through systematic review of published scientific literature.
• Tissue and cell-type resolution: Data cover multiple brain regions and blood cell types, supporting regional and cellular specificity analyses.
• Relevance to non-invasive biomarkers: Includes methylation items identified in blood and cell-free DNA studies relevant to diagnostic marker development.

Scientific Applications:

• Biomarker discovery: Supports identification of candidate methylation markers for early diagnosis and blood-based assays.
• Pathogenesis studies: Enables analysis of DNA methylation changes to elucidate epigenetic contributions to Alzheimer's disease mechanisms.
• Regional and cell-type analyses: Facilitates comparison of methylation patterns across brain regions and blood cell types.
• Translation to non-invasive assays: Provides curated targets for developing cell-free DNA–based diagnostic approaches.

Methodology:

Systematic literature review and manual curation to extract differentially methylated genes, genomic regions, and CpG sites, with analysis of methylation patterns across various brain tissues and blood cell types.