Advanced Cell Classifier

Advanced Cell Classifier performs automated phenotypic classification of microscopy images using machine learning and image-analysis methods for high-content cellular analysis.


Key Features:

  • Machine Learning Integration: Leverages machine learning algorithms to automate interpretation and classification of high-content imaging data.
  • Image Analysis Capabilities: Applies image-analysis techniques to process microscopy images and quantify cellular phenotypes.
  • Phenotype Discovery: Mines image datasets to identify novel and rare cellular phenotypes.
  • Improved Recognition Performance: Refines recognition algorithms to increase accuracy and reliability of phenotype classification.

Scientific Applications:

  • High-Content and High-Throughput Screening: Automates phenotype identification in high-content and high-throughput cell-based screening experiments.
  • Large-Scale Dataset Analysis: Processes and analyzes large image datasets to support scalable phenotypic studies.
  • Disease Mechanism and Cellular Response Studies: Facilitates discovery of phenotypes relevant to disease mechanisms and cellular responses.
  • Quantitative Phenotypic Profiling: Enhances the precision of quantitative phenotypic profiling through improved classification accuracy.

Methodology:

Combines machine learning and image analysis to explore large high-content datasets, addresses the bottleneck of identifying relevant annotated examples for model training, and streamlines the training phase to adapt classifiers to new datasets and experimental conditions.

Topics

Details

License:
GPL-3.0
Tool Type:
desktop application
Operating Systems:
Linux, Windows, Mac
Programming Languages:
MATLAB
Added:
8/4/2018
Last Updated:
1/15/2019

Operations

Data Inputs & Outputs

Publications

Piccinini F, Balassa T, Szkalisity A, Molnar C, Paavolainen L, Kujala K, Buzas K, Sarazova M, Pietiainen V, Kutay U, Smith K, Horvath P. Advanced Cell Classifier: User-Friendly Machine-Learning-Based Software for Discovering Phenotypes in High-Content Imaging Data. Cell Systems. 2017;4(6):651-655.e5. doi:10.1016/j.cels.2017.05.012. PMID:28647475.

PMID: 28647475
Funding: - SNF: 313003A_166565 - FiDiPro Fellow: 40294/13 - European Union and the European Regional Development: GINOP-2.3.2-15-2016-00026, GINOP-2.3.2-15-2016-00037

Documentation