ADVP

ADVP aggregates and harmonizes genetic association data related to Alzheimer's Disease to provide a centralized, annotated repository of variant and association information for research.

Key Features:

• Comprehensive Data Collection: ADVP V1.0 catalogs 6,990 associations across more than 900 loci, over 1,800 variants, and includes data from more than 80 cohorts spanning eight different populations.
• Systematic Review and Harmonization: The platform systematically reviews GWAS publications to extract top genetic associations and harmonizes and annotates them with genomic details.
• Integration with Functional Evidence: ADVP integrates with NIAGADS Alzheimer’s GenomicsDB to cross-reference additional functional evidence related to the genetic variants.

Scientific Applications:

• High-confidence association discovery: Enables exploration and prioritization of high-confidence genetic associations with Alzheimer's Disease.
• Population- and tissue-specific architecture analysis: Provides data to investigate population- and tissue-specific genetic architecture of AD.
• Molecular phenotype and neuropathology studies: Facilitates research into disease-risk factors, expression quantitative traits (e.g., eQTLs), endophenotypes, and neuropathology.
• Hypothesis generation and validation: Supports hypothesis generation, replication and validation studies, and translational research involving AD-associated variants.

Methodology:

Systematic review and extraction of top associations from GWAS publications, followed by harmonization and genomic annotation of associations and integration with NIAGADS Alzheimer’s GenomicsDB for functional evidence.