AFRbase

AFRbase catalogs antifungal resistance-associated mutations across fungal proteins to support research on resistance mechanisms and genotypic susceptibility testing.

Key Features:

• Comprehensive Mutation Catalog: AFRbase catalogs 3,691 unique mutations across 29 proteins from 32 fungal species and documents antifungal resistance-associated variants.
• Data Collection Methodology: Data acquisition combines text mining with manual curation to compile mutation records.
• Visualization Tools: Includes mutation visualizations in 2D and 3D formats to examine structural context and potential impacts on protein function.
• Interoperability: Integrates with NCBI and UniProtKB for cross-referencing sequence and protein annotations.

Scientific Applications:

• Genotypic Susceptibility Testing: Supports genotypic susceptibility testing by providing curated mutation data relevant to diagnostic interpretation and treatment planning.
• Research on Resistance Mechanisms: Enables investigation of molecular mechanisms underlying antifungal resistance across multiple fungal species and proteins.
• Predictive Modeling: Supplies mutation datasets suitable for modeling and predicting evolutionary trajectories of antifungal resistance.

Methodology:

Data were collected using text mining complemented by manual curation.