AHTPDB

AHTPDB provides a curated database of experimentally validated antihypertensive peptides, aggregating sequences, IC50/pIC50 values, toxicity/bitterness annotations, source and purification data, and predicted secondary and tertiary structures to support research on angiotensin-I converting enzyme (ACE) inhibition.

Key Features:

• Extensive Peptide Collection: Contains 5978 peptide entries drawn from 35 major sources (including milk, egg, fish, pork, chicken, and soybean) with 1694 unique peptide sequences.
• Sequence and Activity Data: Provides peptide sequences together with inhibitory concentration (IC50) and log inhibitory concentration (pIC50) values.
• Physicochemical Properties: Includes peptide length and molecular mass for comparative analyses.
• Toxicity and Bitterness Annotations: Reports toxicity and bitterness values associated with peptide entries.
• Structural Predictions: Supplies predicted secondary and tertiary structural information for peptides.
• Purification Data: Records purification-related information for experimental replication and analysis.

Scientific Applications:

• Drug Discovery: Supports identification and prioritization of peptide candidates for development as ACE inhibitors.
• Nutritional Science: Informs studies of food-derived peptides and dietary interventions for hypertension management.
• Structural Biology: Enables investigation of relationships between peptide structure and antihypertensive activity using predicted structural data.
• Biotechnology: Guides engineering and optimization of peptides for improved efficacy or reduced toxicity.

Methodology:

Data were manually curated from peer-reviewed research articles and reputable peptide repositories, and entries are limited to experimentally validated antihypertensive peptides.