Alias

Alias converts diverse protein identifiers (aliases) to unified non-redundant protein sequence references to harmonize identifier usage in genomic and proteomic datasets.

Key Features:

• Non-redundant protein sequence database: Maintains an organism-specific non-redundant list of protein sequences with each sequence linked to multiple aliases.
• Identifier mapping: Maps multiple aliases to a single protein sequence to resolve identifier heterogeneity across datasets.
• SOAP web service: Provides a Simple Object Access Protocol (SOAP) interface for automated identifier conversion and integration into computational workflows.

Scientific Applications:

• Data integration: Harmonizes identifiers to combine datasets from different studies or databases using disparate naming conventions.
• Comparative genomics and proteomics: Standardizes identifiers to enable cross-species and large-scale sequence comparisons.
• Functional annotation: Ensures consistent reference to protein sequences to improve accuracy of aggregated functional annotations.

Methodology:

Uses a curated, organism-specific non-redundant protein sequence database that associates each sequence with its aliases and exposes conversion functionality via a SOAP-based web service.