ALIGNSEC

ALIGNSEC facilitates visualization and manipulation of large-scale multiple sequence alignments (MSAs) with integrated protein secondary structure predictions for comparative structural analysis.

Key Features:

• MSA and secondary structure visualization: Displays large-scale multiple sequence alignments alongside predicted protein secondary structures to highlight structural conservation and variation.
• Alignment editing: Provides capabilities to edit and refine multiple sequence alignments.
• ANTHEPROT integration: Functions as a module within the ANTHEPROT package.

Scientific Applications:

• Protein function prediction: Supports inference of functional domains and active sites by examining conserved structural elements within aligned sequences.
• Evolutionary studies: Aids comparison of structural motifs across species and protein families to trace evolutionary relationships.
• Structural biology: Facilitates analysis of how sequence variations impact protein folding and stability by combining sequence and secondary structure information.

Methodology:

Leverages advanced algorithms to predict protein secondary structure directly within multiple sequence alignments.