Allele frequency net

Allele frequency net provides allele frequency data for immune-related genes across global human populations to support population genetics, transplantation, disease association, and immunogenetics research.

Key Features:

• Extensive Data Collection: Frequency data from 1,133 distinct populations representing 608,813 individuals covering polymorphic regions including human leukocyte antigens (HLA), killer-cell immunoglobulin-like receptors (KIRs), major histocompatibility complex Class I chain-related genes, and cytokine gene polymorphisms.
• Demographic Metadata: Associates demographic information with frequency records derived from population studies.
• Bioinformatics Tools: Provides computational tools to analyze the occurrence and distribution of immune gene variants globally.

Scientific Applications:

• Clinical Applications: Supports histocompatibility testing, immunological research, epidemiology studies, and pharmacogenetics by providing allele frequency data for immune genes.
• Population Genetics: Enables studies of human diversity and evolutionary biology through comparison of immune gene variant distributions across populations.
• Disease Association Studies: Facilitates identification of genetic associations with diseases by providing detailed allele frequency information across populations.

Methodology:

Allele frequency data were collected from published population studies and integrated across polymorphic regions of immune-related genes.