Amadis

Amadis compiles and curates experimentally validated associations between gut microbiota and human diseases to support analysis of microbiota–disease relationships.

Key Features:

• Manually Curated Microbiota–Disease Associations: Contains 20,167 experimentally validated associations involving 221 human diseases and 774 gut microbes across 17 species curated from more than 1,000 scientific publications.
• Dynamic Network Construction: Generates microbe–disease association networks that allow analysis of relationships between specific gut microbes and diseases.
• Comprehensive Multi-Study Integration: Integrates microbiota–disease relationships reported across multiple studies to provide a consolidated dataset for microbiome research.

Scientific Applications:

• Disease Mechanism Investigation: Supports exploration of potential mechanisms linking gut microbiota to human disease pathogenesis.
• Microbial Biomarker Identification: Facilitates identification of gut microbial taxa associated with specific diseases.
• Microbiome-Based Therapeutic Research: Assists studies investigating microbiota-targeted therapeutic strategies.

Methodology:

Amadis aggregates microbiota–disease associations through manual curation of experimentally validated relationships reported in peer-reviewed scientific literature and constructs microbe–disease association networks for analysis.