AmiGO 2

AmiGO 2 provides querying, browsing, visualization, and retrieval of Gene Ontology (GO) terms and associated gene product annotations to support functional interpretation of genomic and proteomic datasets.

Key Features:

• Ontology querying and browsing: Enables complex queries across the Gene Ontology (GO) with filtering by ontology categories (biological process, molecular function, cellular component), evidence codes, and annotation extensions.
• Data visualization: Generates hierarchical trees and network diagrams that represent GO term relationships and gene product associations.
• Annotation data access: Provides retrieval of gene product annotation records linking specific genes or proteins to GO terms.

Scientific Applications:

• Functional Genomics: Annotating gene products and interpreting their roles within cellular processes using GO annotations.
• Comparative Biology: Comparing GO annotations across species to identify conserved biological functions and evolutionary relationships.
• Systems Biology: Integrating large-scale GO annotations and relationships to support construction and analysis of cellular process models.
• Drug Discovery and Development: Identifying candidate targets by elucidating gene function and interaction networks via GO annotations.

Methodology:

AmiGO 2 leverages algorithms to manage and query complex ontological data, employs a backend designed to handle large volumes of annotation data, and integrates with other bioinformatics resources to access complementary datasets and analytical tools.