AMYPdb

AMYPdb catalogs bioinformatic data on amyloid precursor proteins to centralize sequences, structural links, and sequence pattern analyses for research into protein misfolding and aggregation associated with Alzheimer's disease, prion diseases, and type II diabetes.

Key Features:

• Extensive Data Integration: Records cover 31 distinct amyloid precursor families comprising 1,705 protein sequences from nearly 600 organisms.
• Bibliographic and Structural Links: Provides links to over 2,300 bibliographic references and more than 1,200 three-dimensional structures of amyloid-related proteins.
• Sequence Pattern Analysis: Generated and analyzed 3,621 amino acid sequence patterns, identifying family-specific patterns and sequences likely involved in misfolding and aggregation.

Scientific Applications:

• Amyloid fibril formation studies: Support investigation of conformational changes leading to amyloid fibril formation.
• Therapeutic target identification: Enable pinpointing of specific amino acid sequences involved in disease mechanisms to identify potential therapeutic targets.
• Comparative and evolutionary analyses: Facilitate comparative studies across organisms to assess evolutionary aspects of amyloid precursor proteins.

Methodology:

Generation and computational analysis of 3,621 amino acid sequence patterns using large-scale sequence analysis methodologies to identify and categorize family-specific patterns implicated in misfolding and aggregation.