AnCorr

AnCorr evaluates coordinate and ordinal correlations between genomic tracks and expression or protein-binding profiles while accounting for inhomogeneity in genome tracks.

Key Features:

• Innovative Analytical Criteria: Implements a novel set of criteria to assess inhomogeneity and correlations between genomic tracks.
• Genome Track Analyzer software package: Implements the analytical methodologies within the Genome Track Analyzer software package.
• Assessment of inhomogeneity: Evaluates distribution patterns within genomic tracks to identify areas of significant variance affecting analyses.
• Coordinate and ordinal correlation calculation: Calculates both coordinate and ordinal correlations between genomic features and profiles.

Scientific Applications:

• Correlation studies: Examines correlations between CpG islands and transcription start sites in the Homo sapiens genome.
• Protein-binding profiles: Analyzes protein-binding site profiles across chromosomes in Drosophila melanogaster.
• Epigenetic marker analysis: Explores relationships between DNA double-strand breaks and histone modifications in the Homo sapiens genome.
• Cross-species TSS strand correlations: Identifies correlations between transcription start sites on forward and reverse strands in Drosophila melanogaster, Caenorhabditis elegans, Mus musculus, Homo sapiens, and Danio rerio.

Methodology:

Assessment of inhomogeneity by evaluating distribution patterns within genomic tracks and calculation of coordinate and ordinal correlations between genomic features using a novel set of criteria.