Animal-APAdb

Animal-APAdb catalogs alternative polyadenylation (APA) profiles across 18 non-human animal species using RNA sequencing data to support comparative and functional analyses of APA events.

Key Features:

• Extensive dataset: Contains APA profiles derived from 9,244 samples spanning 18 species, curated from RNA sequencing data in public databases.
• Algorithmic detection: Identifies APA events using DaPars2 (342,952 events total; median 17,020 per species) and QAPA (315,691 events total; median 17,953 per species).
• Polyadenylation site and motif prediction: Predicts polyadenylation sites (PAS) and motifs near these sites for each included species.

Scientific Applications:

• Exploration of APA patterns: Enables analysis of tissue- and species-specific APA events to investigate regulatory roles in mRNA stability, localization, and translation.
• Comparative genomics and evolutionary studies: Supports cross-species comparisons to study the evolution of APA mechanisms.
• Functional genomics research: Facilitates correlation of APA events with phenotypes or disease states in non-human models.

Methodology:

Characterization of APA profiles from RNA sequencing data from public databases using DaPars2 and QAPA, with prediction of polyadenylation sites (PAS) and nearby motifs for each species.