Animal QTLdb

Animal QTLdb provides a curated repository that links quantitative trait loci (QTL), single nucleotide polymorphism (SNP) association data, and expression QTL (eQTL) to phenotypic traits across livestock species to support genetic and genomic analyses.

Key Features:

• Extensive data repository: Contains 220,401 QTL entries, SNP association data, and eQTL data linking genotypes to 2,210 distinct phenotypic traits.
• CorrDB datasets: Includes 23,552 correlations for 866 traits and heritability data on 1,069 traits from 4,273 entries.
• Literature curation: Data are curated from 3,157 peer-reviewed publications covering seven livestock species.
• Cross-experiment QTL comparisons: Supports comparison of QTL data across experiments to enable integrative analyses.
• Advanced data mapping and ontologies: Employs standardized procedures for mapping across multiple species and genome builds and uses linked ontology terms for structured annotation.

Scientific Applications:

• Genetic marker discovery: Identification of genetic markers associated with economically important livestock traits to inform selective breeding and genetic studies.
• Phenotype–genotype linkage analyses: Linking phenotypic traits to genotypes to investigate the genetic basis of trait variation and heritability.
• Comparative genomics: Comparison of QTL data across species and genome builds to support evolutionary and functional genomics studies.

Methodology:

Rigorous curation including systematic extraction and integration of data from peer-reviewed publications; implementation of standardized procedures for data mapping across species and genome builds; ontology-based annotation using linked ontology terms.