Animal Transcription Factor Database

Animal Transcription Factor Database catalogs transcription factors, transcription co-factors, and chromatin remodeling factors across 50 sequenced animal genomes and provides curated annotations to support studies of gene expression regulation.

Key Features:

• Extensive Coverage: Comprehensive catalog of transcription factors from 72 families systematically characterized across 50 animal species.
• Detailed Annotations: Per-entry annotations include basic information and gene structure, functional domains and potential 3D structures, Gene Ontology (GO) terms, pathways, protein-protein interactions, paralogs and orthologs, and potential TF-binding sites and target genes.
• Inclusion of Co-factors: Collection and annotation of transcription co-factors and chromatin remodeling factors alongside transcription factors.

Scientific Applications:

• Gene Expression Regulation Studies: Enables analysis of transcriptional regulators and their annotated targets to investigate mechanisms of gene expression control.
• Evolutionary Biology: Supports comparative analyses using paralog and ortholog information to trace lineage and functional divergence of transcription factors.
• Functional Genomics: Facilitates identification of potential TF-binding sites and target genes for functional characterization of regulatory elements.
• Systems Biology: Provides protein-protein interaction and pathway annotations to model regulatory networks and cellular processes governed by transcription factors.

Methodology:

Curated 72 TF families through manual literature review and systematically characterized transcription factors by integrating gene structure, functional domain, and interaction network data.