AniProtDB

AniProtDB provides de novo-assembled proteomes and predicted protein and protein-domain annotations derived from reads in the NCBI Sequence Read Archive for 100 species spanning 21 animal phyla to support comparative genomics, functional annotation, and evolutionary biology.

Key Features:

• Comprehensive Proteome Collection: De novo-assembled metazoan proteomes covering 100 species across 21 animal phyla.
• Source Data and Assembly Pipeline: Proteomes generated from publicly available sequence data in the NCBI Sequence Read Archive using a de novo assembly pipeline.
• Predicted Proteins and Protein Domains: Per-taxon predicted protein sets with associated protein-domain annotations.
• Sequence Similarity Searches: Capability to perform sequence similarity searches across all assembled proteomes.
• Taxonomic Breadth: Inclusion of proteomes from a wide range of non-model and traditionally understudied animal phyla.

Scientific Applications:

• Comparative Genomics: Identification of homologous proteins across species for cross-taxon comparisons.
• Functional Annotation: Use of predicted proteins and domain annotations to assign putative functions to protein sequences.
• Evolutionary Biology: Analysis of protein diversity and domain architecture evolution across 21 animal phyla.
• Biomedical Research: Exploration of species-specific or conserved proteins from non-traditional model organisms relevant to biomedical questions.

Methodology:

De novo assembly of reads from the NCBI Sequence Read Archive to produce proteomes for 100 species (21 phyla), followed by protein prediction and protein-domain annotation, with support for sequence similarity searches across assembled proteomes.