AnnotateGenomicRegions

AnnotateGenomicRegions annotates genomic regions with known features to enable mapping and interpretation of large datasets generated by modern genomic technologies.

Key Features:

• Comprehensive annotation options: Provides selection of overlapping and/or neighboring genome annotations, including genes, promoters, and CpG islands.
• Supported organisms and genome builds: Provides annotations for Human (hg18, hg19), Mouse (mm8, mm9, mm10), Zebrafish (danRer7), and Saccharomyces cerevisiae (sacCer2, sacCer3).
• Custom annotations: Accepts user-supplied custom annotation datasets for tailored analyses.
• Embedded and customizable databases: Includes bundled reference annotations and genomes and supports integration of additional annotation datasets.

Scientific Applications:

• Functional Genomics: Associates genomic regions with annotated features to infer potential functions and regulatory mechanisms.
• Comparative Genomics: Enables cross-species analyses using multiple supported genomes to investigate evolutionary conservation and divergence.
• Translational Research: Facilitates identification of clinically relevant human genomic regions linked to disease or therapeutic targets.

Methodology:

Maps user-provided genomic coordinates to a database of known genomic features and retrieves overlapping or neighboring annotations.