AntigenDB

AntigenDB provides a curated database of antigens from pathogenic species, compiling sequences, structures, B- and T-cell epitope annotations, MHC binding properties, biological function, gene expression profiles, and post-translational modifications to support antigen discovery and vaccine development.

Key Features:

• Extensive Antigen Collection: Contains over 500 antigens derived from 44 pathogenic species curated from scientific literature and immunological resources.
• Detailed Antigen Annotations: Each entry includes sequence and structural information plus annotations for B- and T-cell epitopes, MHC binding properties, biological function, gene expression profiles, and post-translational modifications where available.
• Integration with Other Databases: Entries provide links to major internal and external databases to enable cross-referencing of complementary information.
• Inclusion of Antigens without Known Epitopes: Catalogues antigens for which epitope data may be unavailable to broaden potential targets for experimental epitope mapping and vaccine research.
• Regular Data Updates: The database is maintained with periodic updates that incorporate new antigen entries and expanded analytical annotations.

Scientific Applications:

• Vaccine Candidate Identification: Supports identification and prioritization of antigen targets for subunit and epitope-based vaccine design.
• Antigen Discovery and Validation: Facilitates discovery and validation workflows by providing curated sequence, structural, and immunological annotations.
• Epitope Mapping and MHC Binding Studies: Enables selection of antigens for experimental or computational epitope mapping and MHC binding analyses.
• Study of Immune Mechanisms and Pathogen-Host Interactions: Provides structural and functional antigen data to inform investigations of immune responses and host-pathogen biology.

Methodology:

Antigen entries were curated from scientific literature and immunological resources and annotated with sequence and structural data, B- and T-cell epitopes, MHC binding properties, biological function, gene expression profiles, post-translational modifications, and links to internal and external databases.